Birs- 18w5202: Statistical and Computational Challenges in High-Throughput Genomics with Application to Precision Medicine

  1. Title:
    Afromexico genomics project: The genetic ancestry and health of the Afrodescendant population of Mexico.

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    Inferring rare disease risk variants based on exact probabilities of sharing among multiple affected relatives.

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    Genomic analysis tools for familial and case-control sequencing association studies.

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    Characterizing the effect of genetic variants within promoters with distal enhancer functions.

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    A principle curve approach to three-dimensional chromatin configuration reconstruction.

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    Machine learning approaches to classify patients progressing to sepsis.

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    Brazilian initiative on precision medicine: statistical perspectives.

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  8. Title:
    Copy number analysis of circulating cell-free DNA.

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  9. Title:
    Novel and concordant eQTLs from analysis of iPSC-derived megakaryocytes and platelets in the GeneticStudies of Atherosclerosis Risk (GeneSTAR) project.

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  10. Title:
    PulmonDB: a gene expression lung diseases database.

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  11. Title:
    A new method to study the change of miRNAmRNA interactions due to environmental exposures.

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    Combining immune cell repertoire sequencing and functional expression with applications to autoimmune disease.

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    Co-expression patterns define epigenetic regulators associated with neurological dysfunction.

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    Biologist-intelligible alternative splicing analysis of RNA-seq data.

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  15. Title:
    Genomic profiling of normal, premalignant and heterogeneous tissues in cancer patients.

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  16. Title:
    Proteogenomic analysis of carboplatin response in ovarian cancer cell lines and PDX models.

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  17. Title:
    Statistical methods and software for the study of stem cell differentiation using single-cell transcriptome sequencing.

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  18. Title:
    Single cell whole genome sequencing for population genetic inference of cancer dynamics.

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  19. Title:
    Design and analysis of a single cell RNA-seq benchmarking dataset to compare protocols and methods.

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  20. Title:
    Reproducible and replicable comparisons of methods controlling false discoveries in computational biology.

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