Talk page

Title:
Optimal curvature in long-range cell-cell communication

Speaker:
Jun Allard

Abstract:
Cells in tissue can communicate short-range via direct contact, and long-range via diffusive signals. In addition, another class of cell-cell communication is by long, thin cellular protrusions that are ~100 microns in length and ~100 nanometers in width. These so-called non-canonical protrusions include cytonemes, nanotubes, and airinemes. But, before establishing communication, they must find their target cell. Here we demonstrate airinemes in zebrafish are consistent with a finite persistent random walk model. We study this model by stochastic simulation, and by numerically solving the survival probability equation using Strang splitting. The probability of contacting the target cell is maximized for a balance between ballistic search (straight) and diffusive (highly curved, random) search. We find that the curvature of airinemes in zebrafish, extracted from live cell microscopy, is approximately the same value as the optimum in the simple persistent random walk model. We also explore the ability of the target cell to infer direction of the airineme’s source, finding the experimentally observed parameters to be at a Pareto optimum balancing directional sensing with contact initiation.

Link:
https://mathtube.org/lecture/video/optimal-curvature-long-range-cell-cell-communication

Workshop:
Mathtube- Mathematical Biology Seminar